![]() However, the gut microbiota plasticity (i.e. We found no specific bacterial signatures associated with weight loss that were consistent across both cohorts. ![]() ![]() An additional 157 fecal samples were sequenced from the discovery cohort after 10 weeks of dietary intervention. A total of 161 pre-diet fecal samples were sequenced from a discovery cohort (n = 66) and 106 from a validation cohort (n = 56). We examined the hypothesis that structural differences in the gut microbiota explain a portion of variability in weight-loss using two cohorts of obese adults enrolled in the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) study. While low-carbohydrate and low-fat diets can both lead to weight-loss, a substantial variability in achieved long-term outcomes exists among obese but otherwise healthy adults. ![]()
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